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Lab Manager Flow Cytometry – Fred Hutch Cancer Center posted 11/13/2024
Location: Seattle, Washington
Description:
The Flow Cytometry Services Manager is an integral leadership position within Cellular Therapeutics Program (CTP). CTP is comprised of four functional groups with responsibility for the production and management of clinical cellular products for patient treatment: Apheresis Unit at Fred Hutch, Cellular Therapy Laboratory (CTL), Quality Assurance (QA), and Cellular Therapy Services (CTS).
The Flow Cytometry Services Manager will assist Medical and Scientific Directors with development, implementation and management of new and updated clinical flow cytometry assays.
Job responsibilities include operational and technical oversight of preparation of biological samples and data analysis of flow cytometry testing, troubleshooting and maintenance of flow cytometers and creation and maintenance of lab protocols and lab workflows to ensure flow cytometry testing quality, patient safety, efficiency and compliance with standards, regulations and guidelines.
Responsibilities
- Demonstrate leadership in developing and implementing operational and strategic initiatives for Fred Hutch Flow Cytometry Services.
- Collaborate with the Medical and Scientific Directors on design, validation and implementation of clinical flow assays.
- Responsible for clinical software validation and implementation, as applicable.
- Responsible for flow cytometry service operations:
- Manage daily flow sorting operation
- Daily technical and operational support of flow cytometry assays, such as instrument issues and process improvements.
- Data preview and reporting.
- Oversee quality control and proficiency testing.
- Monitor instrument performance and coordinate the maintenance.
- Participate in clinical trials assays set-up and management, contracting and service agreement negotiation.
- Develop new flow cytometry panels on conventional flow cytometry instruments and spectral flow cytometry.
- Collaborate with the clinical and administrative leadership on clinical trial cost accounting, budgeting, and billing.
- Play a vital role in coordinating service activities, maintaining compliance, and fostering a culture of excellence within the team.
- Maintain professional and technical knowledge by attending educational workshops; reviewing professional publications; establishing personal networks; participating in professional societies.
- Supervise and/or mentor staff in flow cytometry service and provide guidance, support, and training to ensure efficient effective performance. Participate in assessing staff competency.
Qualifications
Required:
- Have earned a bachelor’s degree in a chemical, biological, clinical or medical laboratory science, or medical technology from an accredited institution or meet other education requirements under 42 CFR 493.1449
- Minimum 4 years’ post-degree experience with bachelor’s degree in clinical flow service and flow assay development & validation OR minimum 2 years’ post-degree experience in clinical flow service and flow assay development & validation with master’s degree or higher
- At least 2 years’ laboratory leadership experience working with personnel and projects in CLIA clinical laboratory. Knowledge and/or experience with clinical genomic applications is optional but favored.
- Practical in-depth expertise in flow cytometry in CLIA clinical laboratory.
- Proven experience working effectively with clinicians, administrators and researchers in a multi-disciplinary environment and across organizational lines to achieve excellent outcomes.
- Experience with process and equipment validations. Working knowledge of laboratory equipment management.
- Experience in multiparameter diagnostic flow cytometry, cell sorting for diagnostic applications and antibody-based cell enumeration (e.g. CD34) assays.
- Experience in supporting clinical trials and clinical laboratory Quality Management System is a strong plus.
- Strong leadership abilities.
- Ability to understand and interpret complex written materials and technical reports.
- An effective planner with strong skills in scheduling and organizing work processes.
- Self-motivated, detail oriented, highly organized and able to multitask and work within a rapidly changing environment
- Ability to alternate between being a leader and an individual contributor.
Preferred:
- Master’s degree or higher
- 7 years or more of total experience is preferred.
- ASCP certification in either Medical Laboratory Science general or flow certification.
- Knowledge and/or experience with clinical genomics is optional but a plus for potential lab expansion.
- Experience in a large, complex ambulatory cancer center is desired. Ideally there will be experience working in clinical CLIA laboratory, academic and research environment
Staff Scientist – Protein Conjugation & Flow Cytometry SLiNGSHOT Biosciences
Location: Emeryville, California
Description:
Slingshot Biosciences is a growing life sciences company with a platform technology and paradigm-shifting mission to make synthetic cells the gold standard for all cell-based applications. We currently have a suite of products that allow for rapid, stable instrument deployment and are poised to make headway into clinical markets with controls for engineered cell therapies. At Slingshot, we value diversity and believe that a variety of backgrounds and experiences leads to more innovative ideas and a better understanding of our customers. Passion is at the core of our values, and employees are encouraged to pursue their passions in their work and contribute to the company’s overall mission. We desire motivated team members who appreciate the freedom to be creative and think outside the box to solve problems. We offer an environment where employees are empowered to take ownership of their work and to contribute new ideas. In everything we do, we are dedicated to delivering top-quality products to positively impact patient care.
The Staff Scientist (Scientist 3), Protein Chemistry role will report to the Director of Biochemistry. They will join our team and help in the production of biochemically modified synthetic cells for the development of both custom and/or catalog products. They will also facilitate the transfer of our products from R&D to process development and manufacturing. To be successful, the Staff Scientist, Protein Chemistry will need experience in protein conjugation, working with various types of bioconjugation chemistries and understanding of both biochemistry and how to handle proteins. Familiarity with flow cytometry is preferred for product QC. This role will be a management and leadership position, and the candidates should have experience with managing direct reports, and be excited about bringing innovation and new ideas to the team. The Staff Scientist, Protein Chemistry should be comfortable writing technical reports and analyses of findings, with the goal of leading development projects and reporting and presenting results clearly to management and external stakeholders. This position will be on-site in Emeryville, CA. We are a small but growing team, and the applicant must be comfortable in a dynamic, fast-paced environment. Self-motivated and driven applicants of all experience levels are encouraged to apply.
Responsibilities
- Contribute to R&D efforts in the biochemistry group, with a focus on development of products intended for flow cytometry applications. This work will be supporting the production of our custom products pipeline.
- Protein conjugation related product development work
- Antibody panel design for Flow Cytometry based assays
- Flow cytometry assays on different conventional and spectral flow cytometry instrumentation
- Employ bioconjugation techniques to various biomarkers of interest for the development of synthetic cells and suggest new ideas to improve ongoing conjugation work.
- Do deep dives of literature to determine the best experimental plans based on precedent, and independently drive and troubleshoot projects with your direct report(s).
- Help develop and test new products addressing customer needs in the cell therapy and diagnostics space, and represent the biochemistry team at the project meetings.
- Designing experiments to pressure test protocols to ensure their robustness. Diligent and detailed record keeping of experimental protocols.
- Transfer protocols and SOPs to the process development and manufacturing groups as needed
- Work in the lab on independent projects while also managing a direct report who will support those projects
- Lead projects and drive innovation
- Train and mentor direct reports
- Assign projects, plan their experiments and support troubleshooting while working on your own research projects and managing timelines
- Report team’s progress to management
Requirements
- Ph.D. in a relevant field with 6-8 years of industry experience, or equivalent
- Background in biochemistry, protein chemistry, chemical biology, molecular biology, or an equivalent field
- Experience with management and mentorship while also working on their own experimental projects
- Experience with conjugation chemistry
- Experience with flow cytometry
- Experience with protein purification and basic molecular biology is nice to have
- Able to multitask, prioritize and manage time effectively.
- Strong communication and presentation skills
Nice to have
- Understanding of relevant steps of gene-to- protein process, including construct design, molecular cloning, protein expression, purification, and characterization (bacterial and/or mammalian systems)
- Experience in developing and optimizing purification protocols for different recombinant proteins (with and without affinity tags) using various chromatographic methods (affinity, IEX, SEC, etc) and purification systems (e.g., AKTA)
- Understanding or interest in the cell therapy and diagnostics space
Our salary ranges are calculated by role and level. Your position within that range will be determined by your job-related knowledge, skills, experience, relevant education, and training/certifications. In addition to those factors, we also examine internal equity as well as consider current market rate, and title may be assessed one level lower or higher accordingly. After you join the company your performance, contributions, and results along with business and organizational needs will affect your base salary. The base salary range for this full-time position is between $145,000 – $185,000 + equity + benefits.